MAT Member Handbook_09302026

About Methadone Methadone is a long-acting, synthetic (“man-made”) opiate. It is taken daily. Unlike buprenorphine, there is no risk in precipitating withdrawal when starting methadone. To be safely started, methadone is prescribed at a low dose and increased slowly under medical supervision. While the dose is being titrated, it is not uncommon to continue to experience cravings and withdrawal. This does not mean that the medication is not working. It just means that you are not yet on a stable dose. As the dose is increased, these symptoms go away. When on a stable dose of methadone, individuals are free from cravings, withdrawal and continued use of their drug of choice and show no signs of sedation. They are able to go about their daily lives free from the negative symptoms of a substance use disorder. Methadone is highly regulated by the DEA when used to treat opioid use disorder. It cannot be sent to a pharmacy and can only be obtained from an Opioid Treatment Program (OTP). As individuals progress in treatment, their level of take-homes is increased accordingly. Methadone is longer acting than fentanyl, heroin or other opioids. An adequate oral dose remains fully effective for 24 hours or longer in stalling the onset of withdrawal. This is why methadone needs to be taken only once instead of several times each day. Effects Methadone should be used with caution and in reduced doses for members who are also receiving other pain medication, tranquilizers, sleeping pills, tricyclic antidepressants and other central nervous system depressants, including alcohol. Decreased breathing, decreased blood pressure, heavy sedation and unconsciousness may otherwise result. PLEASE NOTE: If you are on any other medication, you are required to notify the medical staff. There may be some side effects associated with use of methadone. If you are experiencing any unusual symptoms, please contact the medical staff. Side effects may include swelling of the hands and feet, upset stomach, or irregular menstrual periods. To decrease the possibility of an upset stomach, we suggest that members eat before taking methadone and avoid citrus juices near the time of dosing. While there may be some side effects of methadone treatment, goals that may be achieved while on the program include improvements in:

Mental health Physical health Economic status Social status Improved employability Personal freedom Self-esteem

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